ISMP 2016 was held from 27-28th August 2016 in Bayview Hotel, Batu Ferringhi, Penang, Malaysia in conjunction with an International Oncology Symposium (IOS 2016) organised by a premier Malaysian medical institute with cancer research as one of the thrust, Advanced Medical & Dental Institute of Universiti Sains Malaysia. For the 10th anniversary, the conference is renamed the International Conference on Medical Physics to recognise the diversity of the conference speakers and attendees in the 8th (2012) and 9th (2014) conference series. The change has encouraged more international participants especially from the neighboring countries of Malaysia and beyond to come together in “Fostering (Medical Physics) Research and Clinical Practice for Better Healthcare” in this region. The conference accepted abstracts for oral and poster presentations in the topics of radiotherapy physics and imaging physics. Clinical oncology papers can also be submitted and presented at the International Oncology Symposium held in parallel. As in the previous conference, accepted papers were published in the Journal of Physics: Conference Series (JPCS) by the Institute of Physics UK.